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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are usually focused on practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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Pragmatic Software, a software firm offers a range of casino games to online gambling platforms. Pragmatic's iGaming software is used by top operators as well as land-based casinos. The company offers front-end website design tools, analysis and marketing, promotions security, payment systems, customer support and bug reporting. The company also provides security, high-quality graphics, games and security.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from various geographical areas. This type of heterogeneity is required for practical trials to be valid and helps to reduce the chance of bias in the results. A high degree of heterogeneity, however, can cause problems with the design of the trial.
Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers an array of traditional table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta offer an authentic gambling experience for customers, as well as a wide range of virtual betting options. The company also hosts a variety of game shows that make online gambling more exciting and interactive. Some of these shows are broadcast live and others are hosted by famous personalities from the industry.
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Legality
Pragmatic Play is renowned for its top-notch games, and for offering an exceptional user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. Despite its relative youth it has established itself as a top casino gaming platform. The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.
The aim of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are typically ordered by policymakers and practitioners in order to guide their decisions. They can also be used to determine the causality of an intervention and its results. However, they should not be used in lieu for explanation trials.
The concept of pragmatism is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the clinical or physiological hypothesis, and pragmatic trials, which inform policy and practice decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic study, including the recruitment, design, and delivery of the intervention and follow-up.
There is an encouraging increase in the number of pragmatic trials that are published. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of these trials were conducted in primary care settings.