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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically characterized by a focus on the practical aspects of the study design, including the recruitment and consent process as well as adherence to the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from different geographical regions. This type of heterogeneity that is crucial for pragmatic trials to be reliable and reduce bias in results is also essential. A high degree of heterogeneity, however, can cause problems with the trial design.

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Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work with mobile devices and supports different languages. It has established itself as one of the leading gaming platforms for casinos despite its relative infancy. Wolves is one of its latest releases that is a 5-reel slot machine with a healthy RTP and 프라그마틱 슬롯 무료체험 stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. Usually, they are ordered by policymakers and practitioners to help inform their decisions. They can also be used to assess the cause-effect relationship of an intervention and its effects. They should not, however, be used to replace explanation studies.

The pragmatism idea is controversial, 프라그마틱 슬롯 무료 and there are concerns about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study which includes the recruitment, design, and delivery of the intervention and follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This is a sign that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to note, however, that the majority were conducted in primary care settings.