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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of study design, including recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographic areas. This type of heterogeneity which is essential for 프라그마틱 슬롯 추천 pragmatic trials to be reliable and lessen the chance of bias, is also necessary. Too much heterogeneity, however, can cause problems with the design of the trial.

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The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum validity externally. Usually, they are requested by practitioners and policymakers in order to guide their decisions. They can also be used to determine the causal relationship between an intervention with its outcomes. However, they should not be used in lieu for explanatory trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study which includes the recruitment process, the design and 프라그마틱 무료체험 슬롯버프 delivery of the intervention, as well as the follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority were conducted in primary care settings.