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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of study design, including recruitment and consent, adherence and the use routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed different investigators and included participants from different geographic areas. This kind of heterogeneity is essential for practical trials to be valid, and it also reduces the chance of bias in the results. However too much heterogeneity could result in issues with the design of the trial.

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Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software is accessible on mobile devices and in a variety of languages. Despite its relatively young age it has established itself as a leading casino gaming platform. Wolves is one of the most recent releases, a 5-reel slot machine with a healthy RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

The aim of pragmatic trials is to simulate real-life situations and achieve the highest level of validity externally. They are typically commissioned by policymakers and practitioners to guide their decisions. They can also be used to assess the causality of an intervention and its results. However, they should not be used to replace the need for explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which prove the validity of a clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a practical study which includes the recruitment, design, and delivery of the intervention and its follow-up.

There is a positive increase in the number pragmatic trials that are published. A recent Medline search using the terms pragmatic and 프라그마틱 홈페이지 naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is an indication that the health sciences community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.