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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as focusing on practical aspects of design which include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is essential for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They can be used to determine the causality of an intervention with its outcomes. They should, however, not, be used to replace explanation studies.

The idea of pragmatism is controversial and there are concerns regarding whether pragmatic trials could be used to replace explanation tests or if they should be an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm the validity of a physiological or 프라그마틱 카지노 clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study which includes recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This is a sign that the health sciences community is becoming more sensitive to the subject of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary-care settings.