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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically focused on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.
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A practical trial that employs various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, that is crucial for
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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are usually commissioned by policymakers and practitioners to help guide their decisions. They can be used to determine the cause-effect relationship of an intervention and its effects. However, they should not be used to substitute for 프라그마틱 불법,
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The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which confirm the clinical or physiological hypothesis, and pragmatic trials, which guide the policy and practice of. They also proposed a framework for pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic trial that include recruitment, design and delivery of the intervention, and follow-up.
There is a positive increase in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note that the majority of these trials were conducted in primary care settings.