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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of study design that include recruitment and consent, adherence and the use of standard equipment.
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Pragmatic is a software company provides a variety of casino games for online gambling platforms. Its iGaming software is used by leading operators as well as casinos that are located in the land. The company offers front-end website design tools, analysis tools and
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from various geographical areas. This type of heterogeneity is necessary for practical trials to be valid and reduces bias in the results. A high degree of heterogeneity, however, can cause problems with the trial design.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policymakers and practitioners to help inform their decisions. They are also a good way to identify the causality between an intervention and its outcomes. They should, however, not be used to replace explanatory studies.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a practical trial, including the recruitment process, the design and delivery of the intervention,
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The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatism. It is important to keep in mind that the majority were conducted in primary-care settings.