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Pragmatic trials are studies designed to provide information for real-world clinical practice. They are often characterized as a focus on the practical aspects of study design, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Pragmatic Software, a software firm offers a range of casino games for online gambling platforms. Its iGaming software is used by leading operators as well as land-based casinos. The company offers front-end tools for design, analysis, promotions, marketing, payment systems, security, customer service and bug reporting. The company also offers security, high-quality graphics, games and security.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is essential for pragmatic trials to be able to prove their validity and helps to reduce bias in the results. However, too much heterogeneity, can cause problems with the trial design.
Pragmatic Play is also a major player in the live casino market, providing a wide selection of table games like as Blackjack and Roulette in a variety of versions. The live studios of the company in Romania and Malta provide customers with an authentic experience in gambling and a wide variety of betting options via virtual. The company also hosts a variety of game shows that make online gambling more fun and interactive. Some of these shows feature a live host, while others are hosted by famous personalities from the industry.
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Legality
Pragmatic Play is renowned for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work with mobile devices and supports multiple languages. Despite its relative youth it has established itself as a premier gaming platform for casinos. Wolves is one of the most recent releases which is a five-reel slot machine that has a high RTP and stunning graphics. Its other notable titles are Wolf Gold and Chilli Heat.
Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be used to determine the causality of an intervention with its outcomes. However, they should not be used to substitute for explanatory studies.
The idea of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they should be a complement to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the clinical or physiological hypothesis and pragmatic trials, which guide the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study that includes recruitment, design, delivery of the intervention and its follow-up.
There is an encouraging trend in the number of pragmatic trials published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs) produced 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these trials were conducted in primary care settings.