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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described by their focus on practical aspects of designing a study which include the recruitment process and consent, adhering and the use routinely available equipment.
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A pragmatic study that involves various investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for a pragmatic trial to be valid and to reduce bias in the results is also essential. However, too much heterogeneity can cause problems with the design of the trial.
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Legality
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The purpose of pragmatic trials is to mimic real-life situations and achieve maximum credibility externally. They are usually commissioned by practitioners and policy makers to inform their decision making. They also provide a useful way to identify the causal relationship between an intervention and its outcomes. However, they should not be used to substitute for explanation trials.
The pragmatism idea is controversial and there are concerns about whether pragmatic trials can replace tests for explanations or if they are an alternative to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the clinical or physiological hypothesis and pragmatic trials,
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just click the following post) which inform the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the traits of a practical study that includes the recruitment, design, and delivery of the intervention, and follow-up.
There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs), yielded 34 articles, which are shown in red in Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority were conducted in primary care settings.