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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of study design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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A pragmatic study that involves different investigators and participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is necessary for pragmatic trials to be valid and helps to reduce the chance of bias in the results. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic Play is known for its top-quality games and for offering an exceptional user experience. Its software is accessible on mobile devices as well as in various languages. It has been recognized as one of the most popular casino gaming platforms despite its relatively young age. Its latest releases include Wolves, a 5-reel video slot with a healthful RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually requested by policy makers and practitioners to aid in their decision-making. They can also be used to assess the causal relationship between an intervention and its results. However, they should not be used in lieu for explanatory trials.

The idea of pragmatism is controversial and there are concerns about whether pragmatic trials should replace tests for explanations or if they should be an addition to them. Schwartz and Lellouch1 made the distinction between explanation studies, which confirm the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a practical study that includes recruitment, design, implementation of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. It is important to remember that the majority were conducted in primary care settings.