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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on practical aspects of the research design, like recruitment and consent as well as adherence to the use of commonly available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and included participants from various geographical areas. This type of heterogeneity which is essential for a pragmatic trial to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. Usually, they are requested by practitioners and policymakers to guide their decisions. They are also a good way to identify the causality between an intervention and its outcomes. However, they should not be used in lieu for the use of explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or 프라그마틱 사이트 clinical hypothesis as well as pragmatic trials that inform policy and practice decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the features of a pragmatic trial that include the recruitment process, the design and implementation of the intervention, as well as monitoring.

The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials that are randomized (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is a sign that the health sciences community is becoming more acquaint to the issue of pragmatics. It is important to keep in mind, however, that the majority of studies were conducted in primary-care settings.